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by D. Schindler,H. Hoehn,M. Schmid
Download Fanconi Anemia: A Paradigmatic Disease for the Understanding of Cancer and Aging (Monographs in Human Genetics, Vol. 15) fb2
Biological Sciences
  • Author:
    D. Schindler,H. Hoehn,M. Schmid
  • ISBN:
    3805582773
  • ISBN13:
    978-3805582773
  • Genre:
  • Publisher:
    S. Karger; 1 edition (May 15, 2007)
  • Pages:
    230 pages
  • Subcategory:
    Biological Sciences
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  • DJVU format
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In: Schindler D, Hoehn H (eds) Fanconi anemia: a paradigmatic disease for the understanding of cancer and aging, vol 15, Monographs in human genetics. Karger, Basel, pp 59–78CrossRefGoogle Scholar. 9. Howlett NG (2007) Fanconi anemia: Fanconi anemia, breast and embryonal cancer risk revisited. Eur J Hum Genet 15:715–gle Scholar. epartment of Human GeneticsBiozentrum University of any. epartment of Human GeneticsRadboud University Nijmegen Medical CenterNijmegenThe Netherlands. Cite this entry as: Schindler . Neveling . Endt D. (2011) Fanconi Anemia.

A paradigmatic disease for the understanding of cancer and aging, vol 15, Monographs in human genetics. Schindler . Endt . Neveling K. (2015) Fanconi Anemia. In: Schwab M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. Karger, Basel, pp 59–78Google Scholar. Neveling K, Endt D, Hoehn H, Schindler D (2009) Genotype-phenotype correlations in Fanconi anemia. Mutat Res 668:73–le Scholar.

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Items related to Fanconi Anemia: A Paradigmatic Disease for the Understanding. Fanconi anemia (FA) is a rare genetic disease discovered 80 years ago by Guido Fanconi, an eminent Swiss pediatrician. Fanconi Anemia: A Paradigmatic Disease for the Understanding of Cancer and Aging (Monographs in Human Genetics, Vol. 15). ISBN 13: 9783805582773. It is characterized by short stature, skeletal anomalies, increased incidence of solid tumors and leukemias, bone marrow failure and cellular sensitivity to DNA damaging agents.

Monographs in Human Genetics. S. Karger AG (Switzerland). We're committed to providing low prices every day, on everything.

Published: 1 November 2008.

Schindler D, Hoehn H. Fanconi Anemia: A Paradigmatic. Disease for the Understanding of Cancer and Aging. recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ. Mech Ageing Dev 2008;129:425-40. 5. Alter BP. Diagnosis, genetics, and management of. inherited bone marrow failure syndromes.

Fanconi anemia (FA) is a recessively inherited disease characterized by multiple symptoms including growth retardation, skeletal . Fanconi Anemia: A Paradigmatic Disease for the Understanding of Cancer and Aging. Dietrich Schindler, Heinrich Hoehn.

Fanconi anemia (FA) is a recessively inherited disease characterized by multiple symptoms including growth retardation, skeletal abnormalities, and bone marrow failure. The FA diagnosis is complicated due to the fact that the clinical manifestations are both diverse and variable.

View at Google Scholar · View at Scopus.

Articles focusing on patient care, health systems, epidemiology, and animal models will be considered, among other relevant topics. View at Google Scholar · View at Scopus. D. Schindler and H. Hoehn, Fanconi anemia a paradigmatic disease for the understanding of cancer and aging, Monographs in Human Genetics, vol. 15, pp. 1–13, 2007. View at Google Scholar.

Fanconi anemia (FA) is a rare genetic disease discovered 80 years ago by Guido Fanconi, an eminent Swiss pediatrician. It is characterized by short stature, skeletal anomalies, increased incidence of solid tumors and leukemias, bone marrow failure and cellular sensitivity to DNA damaging agents. Following a historical account, exemplary case reports and the current status of FA genes and their mutations, this volume discusses neoplasia in FA as well as current approaches to pre- and postnatal diagnosis. Further topics include revertant mosaicism as a kind of ‘natural gene therapy’ and hematopoietic stem cell transplantation as the only curative approach in FA. The final chapters investigate evolutionary aspects of the FA genes with special emphasis on the avian genome and the involvement of FA genes in recombinational types of DNA repair. Physicians and researchers in the fields of pediatrics, hematology, cancer, genetics, DNA repair and aging will benefit from understanding this disease, which illustrates the complex network of genomic maintenance systems that protect us from cancer and premature aging.