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by Paul M. Vanhoutte
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Medicine & Health Sciences
  • Author:
    Paul M. Vanhoutte
  • ISBN:
  • ISBN13:
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  • Publisher:
    Humana Press; 1988 edition (August 24, 1988)
  • Pages:
    544 pages
  • Subcategory:
    Medicine & Health Sciences
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by Paul M. Vanhoutte (Author). Relaxing and Contracting. has been added to your Cart.

by Paul M. ISBN-13: 978-0896031289.

Relaxing and Contracting Factors book. by. Paul M. Vanhoutte.

Endothelium-derived contracting factors appear to be responsible for . The possible physiological roles and pathophysiological significance of endothelium-derived relaxing and contracting factors are briefly discussed.

In all such experiments, the endothelium-derived contracting factor appears to be some product or by-product of cyclooxygenase activity.

New Biological Books.

Recent clinical and laboratory animal studies revealed that increased tonus and spasm of the large epicardial coronary arteries are the cause of various stages of ischemic heart disease. The role of coronary vasospasm in the development of un­ stable angina, sudden cardiac death and acute myocardial infarction remains open to debate.

Find nearly any book by Paul M. Get the best deal by comparing prices from over 100,000 booksellers. by Paul M. ISBN 9780890046029 (978-0-89004-602-9) Hardcover, Raven Pr, 1981.

Since the description of the essential role of the endothelium in mediating .

Since the description of the essential role of the endothelium in mediating relaxations due to acetylcholine in mammalian arteries, it has become obvious that endothelial cells release several relaxing and contracting substances. t relaxations caused by EDRF are induced through increases in the activity of soluble guanylate cyclase in the smooth muscle. Other relaxing factors, such as prostacyclin and endothelium-derived hyperpolarizing factor (EDHF) contribute to t relaxations.

Endothelium-derived relaxing and contracting factors. RF Furchgott, PM Vanhoutte. GM Rubanyi, JC Romero, PM Vanhoutte. The FASEB Journal 3 (9), 2007-2018, 1989. Flow-induced release of endothelium-derived relaxing factor. American Journal of Physiology-Heart and Circulatory Physiology 250 (. 1986. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. GM Rubanyi, PM Vanhoutte.

Member American Society Clinical Investigation (emeritus), American Society Pharmacology and Experimental Therapeutics, Association American Physicians, Association des Pharmacologistes (France), Belgian Society Physiology and Pharmacology, Biophysics Society, British Pharmaceutical Society, International Society Hypertension, International Society Endothelialization in Cardiovasc.

It is an exciting task to be the editor of the first monograph covering a new area of the biomedical sciences. Since the first report in 1980 by Robert Furchgott and colleagues (see Chapter 1) of the evidence of endothelium-dependent relaxation in isolated arteries, there are ever­ increasing numbers of vascular physiologists and pharmacologists who are scraping away the endothelium to look into its role in cardiovascular con­ trol. And the more one looks, the more one discovers. Not only is the list of substances that can induce endothelium-dependent relaxations im­ pressively long, but these intriguing cells can also secrete vasoconstrictor substances. The ability of the endothelium to modulate the degree of con­ traction of the underlying smooth muscle is an ancestral property of the blood vessel wall, illustrating the logic of nature, since the endothelial cells are located in the best possible strategic location to continuously monitor the properties (chemical or physical) of the blood. And more and more data emerge suggesting that in several cardiovascular diseases per­ turbations in endothelium-dependent responses are one of the early signs of the abnormal process. Thus, the importance of endothelium-dependent responses, triggered by the intellectual curiosity of one of the pioneers of vascular physiology and pharmacology, is now recognized not only by basic scientists, but also by all concerned with the cardiovascular diseases. The purpose of this monograph is to provide them with a reference work, so that they know where to start.