- Author:Curtis C. Harris
- Publisher:John Wiley & Sons Inc (May 1, 2000)
- Pages:492 pages
- FB2 format1276 kb
- ePUB format1551 kb
- DJVU format1322 kb
- Formats:lrf rtf mobi txt
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Examples of practical approaches to molecular epidemiology of human cancer are described. Biomarkers of carcinogen exposure or inherited host factors for cancer susceptibility are discussed. The polycyclic aromatic hydrocarbon-DNA adducts are the most extensively studied in this field and together with antibodies to these adducts found in human serum, they have become useful indicators of exposure to carcinogens. Assays for various kinds of alkyl-DNA adducts have also been developed and the presence of these adducts have been documented in human tissues.
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Over the years, molecular epidemiology has become extremely complex, with studies evaluating associations between cancer risk and prognosis and numerous markers of susceptibility, exposure and early effects, as well as epidemiologic factors.
Molecular epidemiology integrates molecular biology, in vitro and in vivo laboratory models, biochemistry. 1998) Molecular Epidemiology of Human Cancer. In: Schwab . Rabes . Munk . Hofschneider . eds) Genes and Environment in Cancer.
Biochemical & Molecular Epidemiology of Cancer. There's no description for this book yet. Biochemical & Molecular Epidemiology of Cancer. 1 2 3 4 5. Want to Read.
Authors and affiliations. Chemically defined media have been developed for culturing many of these tissues and cells from normal organs, including those with a high rate of cancer in humans. Serum-free media have several advantages in studies of cultured human cells, including: (a) less experimental variability compared to serum-containing media; (b) selective growth conditions for normal cells of different types (. epithelial versus fibroblastic) or for normal versus malignant cells; (c) ease of identification of growth factors, inhibitors of growth, and inducers of differentiation; and (d) ease of isolating and.
Information is provided on the nutritional biochemistry of copper, including food sources, intestinal absorption, transport, tissue distribution, and excretion, along with descriptions of copper binding proteins and other factors involved and their roles in these processes. The metabolism of copper and its importance for the functions of a roster of vital enzymes is detailed. Its potential toxicology is also addressed.
Curtis C. Harris, . Harris has a wide range of scientific interests and accomplishments spanning molecular genetics of human cancer to molecular epidemiology of human cancer risk. Laboratory of Human Carcinogenesis. com/watch?v MYUiS Mh7eg).
11. Hussain, S. P. and Harris, C. Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes
Curtis C. Harris, MD. Chief, Laboratory of Human Carcinogenesis, CCR, NCI, NIH. EDUCATION University of Kansas University of Kansas School of Medicine. 11. Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Re. 58: 4023-4037, 1998. 12. Ambs, . Merriam, W. Ogunfusika, M. Bennett, W. Ishibe, . Hussain, P. Tzeng, E. Geller, D. Billiar, T. R. p53 and vascular endothelial growth factor regulate tumor growth of NOS2-Expressing human carcinoma cells. Nature Me. 4: 1371-1376, 1998.